DMPQ- What do you mean by genome sequencing? What are its application.

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Genome sequencing is figuring out the order of DNA nucleotides, or bases, in a genome—the order of As, Cs, Gs, and Ts that make up an organism’s DNA. The human genome is made up of over 3 billion of these genetic letters.

Today, DNA sequencing on a large scale—the scale necessary for ambitious projects such as sequencing an entire genome—is mostly done by high-tech machines. Much as your eye scans a sequence of letters to read a sentence, these machines “read” a sequence of DNA bases.

A DNA sequence that has been translated from life’s chemical alphabet into our alphabet of written letters might look like this:

Application of genome sequencing:

  • Identification of diseases. Whole-genome sequencing is the natural next step: it can survey exonic regions that are
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poorly captured, and be used to detect structural variants.
  • One of the great promises of genomic research is personalized medicine: tailoring disease treatments to an individual’s genetic makeup.
  • Fatal disease like cancer can be cured if more research is done on genetic make up.
  • Identification of family disease pedigrees.
  • well-phenotyped cohorts have always been in high demand for genetic studies.

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